Patrícia de Almeida, Rodrigo Álvaro Brandão Lopes-Martins, Shaiane Silva Tomazoni, Gianna Móes Albuquerque-Pontes, Larissa Aline Santos, Adriane Aver Vanin, Lucio Frigo, Rodolfo P Vieira, Regiane Albertini, Paulo de Tarso Camillo de Carvalho and Ernesto Cesar Pinto Leal-Junior Low-Level Laser Therapy and Sodium Diclofenac in Acute Inflammatory Response Induced by Skeletal Muscle Trauma: Effects in Muscle Morphology and mRNA Gene Expression of Inflammatory Markers Photochemistry and Photobiology 89
Article first published online: 9 OCT 2012 | DOI: 10.1111/j.1751-1097.2012.01232.x
We performed a single trauma in tibialis anterior muscle of rats. Animals were treated with sodium diclofenac (11.6 mg g−1 of solution) or LLLT (810 nm; continuous mode; 100 mW; 3.57 W cm−2; 1, 3 or 9 J). Histological analysis and quantification of gene expression of COX-1, COX-2 and TNF-α were performed at 6, 12 and 24 h after trauma. LLLT improved morphological aspects of muscle tissue showing better results than injury and diclofenac groups. LLLT decreased COX-2 compared to injury group at all time points, and to diclofenac group at 24 h after trauma. In addition, LLLT decreased TNF-α compared to injury and diclofenac groups at all time points.
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