Rodrigo Leal de Paiva Carvalho, Ernesto Cesar Pinto Leal-Junior, Maria Carla Petrellis, Rodrigo Labat Marcos, Maria Helena Catelli de Carvalho, Gilberto De Nucci and Rodrigo Alvaro Brandão Lopes-Martins Effects of Low-Level Laser Therapy (LLLT) and Diclofenac (Topical and Intramuscular) as Single and Combined Therapy in Experimental Model of Controlled Muscle Strain in Rats Photochemistry and Photobiology 89
The aim of this study was to evaluate the effect of single and combined therapies (LLLT, topical application of diclofenac and intramuscular diclofenac) on functional and biochemical aspects in an experimental model of controlled muscle strain in rats. Injured groups received either no treatment, or a single treatment with topical or intramuscular diclofenac (TD and ID), or LLLT (3 J, 810 nm, 100 mW) 1 h after injury. All treatments significantly decreased COX-1 and COX-2 gene expression compared with injury group (P < 0.05). However, LLLT showed better effects than TD and ID regarding PGE2 levels and walking track analysis (P < 0.05).
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