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Jee-Young Choi, Da-In Choi, Jee-Bum Lee, Suk-Jung Yun, Dong-Ho Lee, Jong-Bang Eun and Seung-Chul Lee Ethanol Extract of Peanut Sprout Induces Nrf2 Activation and Expression of Antioxidant and Detoxifying Enzymes in Human Dermal Fibroblasts: Implication for its Protection Against UVB-irradiated Oxidative Stress Photochemistry and Photobiology 89

Version of Record online: 6 NOV 2012 | DOI: 10.1111/j.1751-1097.2012.01244.x

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The purpose of this study was to evaluate the cytoprotective activity of ethanol extract of peanut sprout (EPS) from ultraviolet B (UVB)-induced oxidative stress in human dermal fibroblasts (HDF). EPS suppressed UVB-induced ROS production in HDF, as it also inhibited UVB-induced apoptotic cell death. EPS induced up-regulation and nuclear translocation of Nrf2 in HDF. UVB irradiation up-regulated Nrf2-dependent enzymes of HO-1, NQO-1, and GSTpi, and they were further stimulated by EPS treatment. Taken together, EPS is an efficient cytoprotective agent against UVB-induced oxidative stress by activation of Nrf2 and up-regulation of Nrf2-relating antioxidant and detoxifying enzymes in HDF.

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