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Hideaki Yamamoto, Takanori Demura, Mayu Morita, Gary A. Banker, Takashi Tanii and Shun Nakamura Differential neurite outgrowth is required for axon specification by cultured hippocampal neurons Journal of Neurochemistry 123

Version of Record online: 4 OCT 2012 | DOI: 10.1111/jnc.12001

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Axon formation: no growth, no specification

One unsolved question on the mechanism of axon formation by cultured neurons was the role of axon outgrowth in axon specification. Using micropatterned surfaces to extrinsically regulate lengths of individual neurites, we show that differential outgrowth of a future axon is required for axon specification. The results presented here provide clear evidence that an axon cannot be specified without sufficient outgrowth.

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