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Linn H. Nilsen, Torun M. Melø, Oddbjørn Sæther, Menno P. Witter and Ursula Sonnewald Altered neurochemical profile in the McGill-R-Thy1-APP rat model of Alzheimer's disease: a longitudinal in vivo 1H MRS study Journal of Neurochemistry 123

Version of Record online: 1 OCT 2012 | DOI: 10.1111/jnc.12003

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The study of transgenic animals is instrumental to achieve a better understanding of early aspects of Alzheimer's disease. We found prominent metabolite alterations at the pre-plaque stage of 3 months and also during the progression of AD pathology in McGill-R-Thy1-APP rats. The findings demonstrate that in vivo 1H MRS is a powerful tool to investigate disease-related metabolite changes in brain.

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