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Qian Bu, Zhengtao Hu, Feng Chen, Ruiming Zhu, Yi Deng, Xue Shao, Yan Li, Jinxuan Zhao, Hongyu Li, Baolai Zhang, Lei Lv, Guangyan Yan, Yinglan Zhao and Xiaobo Cen Transcriptome analysis of long non-coding RNAs of the nucleus accumbens in cocaine-conditioned mice Journal of Neurochemistry 123

Article first published online: 25 OCT 2012 | DOI: 10.1111/jnc.12006

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Cocaine Modifies Transcriptional Profiling of lncRNAs

LncRNAhas been shown to be involved in various neurological diseases;however, itsrole in drug addiction is unknown. Here, we identified 603 lncRNAs changed significantly in brain nucleus accunbens of cocaine-dependent mice, providing 48 pair mRNA-lncRNAs significantly modified. These findings provide for the first time new insights intothepotentialinvolvement of lncRNAs in neuroplasticity and drug addiction.

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