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Jonathan A. Roberts, Andrew R. Bottrill, Sharad Mistry and Richard J. Evans Mass spectrometry analysis of human P2X1 receptors; insight into phosphorylation, modelling and conformational changes Journal of Neurochemistry 123

Version of Record online: 11 OCT 2012 | DOI: 10.1111/jnc.12012

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Mapping movement and phosphorylation of human P2X1 receptors

Mass spectroscopic analysis of purified P2X1 receptors was used to gain insight into receptor phosphorylation and conformational changes. The P2X1 was basally phosphorylated at three positions and cross-linking adjacent receptor subunits inhibited function. The basal phosphorylation was not essential for normal function however significant movement was required in the extracellular domain for receptor activation.

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