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Hayley M. Bennett, Kristin Lees, Kate M. Harper, Andrew K. Jones, David B. Sattelle, Susan Wonnacott and Adrian J. Wolstenholme Xenopus laevis RIC-3 enhances the functional expression of the C. elegans homomeric nicotinic receptor, ACR-16, in Xenopus oocytes Journal of Neurochemistry 123

Article first published online: 10 OCT 2012 | DOI: 10.1111/jnc.12013

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Xenopus laevis RIC-3 enhances the functional expression of the C. elegans homomeric nicotinic receptor, ACR-16, in Xenopus oocytes.

This study was performed to test the hypothesis that an amphibian RIC-3 would be a more effective chaperone for the expression of certain nicotinic acetylcholine receptors in the Xenopus oocyte system than the mammalian or nematode versions of the protein. We found expression of the C. elegans ACR-16 receptor was detectable in a higher proportion of oocytes when co-expressed with the RIC-3 from Xenopus laevis than with the human or nematode protein. Use of the X. laevis RIC-3 may improve the expression of certain heterologous nicotinic receptors in the Xenopus oocyte system.

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