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Luigina Tagliavacca, Federico Colombo, Gabriella Racchetti and Jacopo Meldolesi L1CAM and its cell-surface mutants: new mechanisms and effects relevant to the physiology and pathology of neural cells Journal of Neurochemistry 124

Version of Record online: 10 DEC 2012 | DOI: 10.1111/jnc.12015

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L1CAM is a TrkA coreceptor

The neural adhesion protein L1CAM works also as a coreceptor. The receptors/mechanisms involved and the changes induced by pathogenetic L1CAM mutations were known only in part. L1CAM and some (but not others) of its mutants were identified as coreceptors of TrkA. The article reveals new aspects of TrkA signaling and new mechanisms of the L1 syndrome (CRASH) pathogenesis. (a) The water-soluble chimera, L1CAM-Fc, reproduces the L1CAM-positive modulation of TrkA when incubated with cells that lack the endogenous adhesion protein. (b–d) Neurite outgrowth induced in PC12-Trk cells (b) by L1CAM-Fc alone (c) or associated to a small concentration of NGF (d).

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