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Guozhang Mao, Mei-Zhen Cui, Tong Li, Yipeng Jin and Xuemin Xu Pen-2 is dispensable for endoproteolysis of presenilin 1, and nicastrin-Aph subcomplex is important for both γ-secretase assembly and substrate recruitment Journal of Neurochemistry 123

Article first published online: 11 OCT 2012 | DOI: 10.1111/jnc.12016

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Pen-2 is dispensable for endoproteolysis of presenilin 1, and nicastrin-Aph subcomplex is important for both γ-secretase assembly and substrate recruitment.

There are still questions remaining unanswered regarding the role of each component of the γ-secretase complex during its maturation and interaction with APP. The most relevant, novel finding of this study is that Pen-2 is dispensable for presenilin endoproteolysis, and the nicastrin-Aph subcomplex is important for γ-secretase assembly and substrate recruitment. This information is critical for understanding how γ-secretase catalyzes APP processing and Aβ formation.

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