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Melissa L. Barker-Haliski, Katharina Oldenburger and Kristen A. Keefe Disruption of subcellular Arc/Arg 3.1 mRNA expression in striatal efferent neurons following partial monoamine loss induced by methamphetamine Journal of Neurochemistry 123

Article first published online: 10 OCT 2012 | DOI: 10.1111/jnc.12017

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Methamphetamine-induced neurotoxicity disrupts Arc expression underlying consolidation of striatally-based learning; however, whether METH-induced neurotoxicity disrupts Arc transcription or trafficking is unknown. We now demonstrate that basal Arc transcription and cytoplasmic expression are elevated, but behaviorally-induced transcriptional activation of Arc is abolished in METH-pretreated rats. These results suggest that Arc or factors regulating it could be targets for addressing METH-induced cognitive impairments.

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