Melissa L. Barker-Haliski, Katharina Oldenburger and Kristen A. Keefe Disruption of subcellular Arc/Arg 3.1 mRNA expression in striatal efferent neurons following partial monoamine loss induced by methamphetamine Journal of Neurochemistry 123
Methamphetamine-induced neurotoxicity disrupts Arc expression underlying consolidation of striatally-based learning; however, whether METH-induced neurotoxicity disrupts Arc transcription or trafficking is unknown. We now demonstrate that basal Arc transcription and cytoplasmic expression are elevated, but behaviorally-induced transcriptional activation of Arc is abolished in METH-pretreated rats. These results suggest that Arc or factors regulating it could be targets for addressing METH-induced cognitive impairments.
Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf