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Masanori Tachikawa, Go Ozeki, Takanori Higuchi, Shin-ichi Akanuma, Kazuhiro Tsuji and Ken-ichi Hosoya Role of the blood–cerebrospinal fluid barrier transporter as a cerebral clearance system for prostaglandin E2 produced in the brain Journal of Neurochemistry 123

Version of Record online: 10 OCT 2012 | DOI: 10.1111/jnc.12018

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An imbalance in the rates of production and clearance of prostaglandin (PG) E2 under pathological conditions appears to affect the concentration of PGE2 in the CSF. This study demonstrated that microsomal PGE synthetase-1 (mPGES-1) is expressed in the pia mater and astrocytes, and a regulatory system for the PGE2 level in the CSF involves OAT3-mediated PGE2 uptake by choroid plexus epithelial cells. The findings provide a novel insight into the production and clearance of PGE2 in the CSF.

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