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Jörg Hanrieder, Titti Ekegren, Malin Andersson and Jonas Bergquist MALDI imaging of post-mortem human spinal cord in amyotrophic lateral sclerosis Journal of Neurochemistry 124

Version of Record online: 28 JAN 2013 | DOI: 10.1111/jnc.12019

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Imaging Mass Spectrometry of Spinal Cord in ALS MALDI imaging mass spectrometry was used for elucidating molecular changes in human spinal cord samples of ALS, a devastating fatal disease, of which the biomolecular pathophysiology remains largely elusive.

The results show differences in protein intensity distribution in human spinal cord as well as significant ALS-related changes in region-specific ubiquitin metabolism.

These findings point towards impaired protein turnover to be essentially involved in ALS pathology.

Read the Editorial Highlight for this article on doi: 10.1111/jnc.12037.

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