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Shireesh Srivastava, Yoshihiro Kashiwaya, Xuesong Chen, Jonathan D. Geiger, Robert Pawlosky and Richard L. Veech Microwave irradiation decreases ATP, increases free [Mg2+], and alters in vivo intracellular reactions in rat brain Journal of Neurochemistry 123

Version of Record online: 7 NOV 2012 | DOI: 10.1111/jnc.12026

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The brain energy profile is distorted by microwave radiation

Because microwave radiation has gained increasing acceptance for brain tissue fixation, the concentrations of a broad range of biochemical intermediates from irradiated tissue were compared to that of freeze-blown brain tissue. Radiation reduced [ATP] and increased [ADP] coinciding with higher levels of intracellular free Mg2+, which gave rise to a novel energetic state. A change to the [Mg2+] modifies selected enzyme rate constants, which distort energy determinants in microwaved brains.

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