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Vincent Fournet, Gaetan de Lavilléon, Annie Schweitzer, Bruno Giros, Annie Andrieux and Marie-Pascale Martres Both chronic treatments by epothilone D and fluoxetine increase the short-term memory and differentially alter the mood status of STOP/MAP6 KO mice Journal of Neurochemistry 123

Version of Record online: 25 OCT 2012 | DOI: 10.1111/jnc.12027

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The microtubule-associated STOP protein deletion triggers altered mood and cognitive performance in mice. Chronic treatments by epothilone D and fluoxetine of STOP KO mice increase their short-term memory. Moreover, STOP KO mice are hypersensitive to acute and chronic stress. These mice represent a valid model to study relationship between cytoskeleton, mood disorders and stress and to test innovative therapeutics.

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