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Alin M. Puinean, Stuart J. Lansdell, Toby Collins, Pablo Bielza and Neil S. Millar A nicotinic acetylcholine receptor transmembrane point mutation (G275E) associated with resistance to spinosad in Frankliniella occidentalis Journal of Neurochemistry 124

Version of Record online: 13 JAN 2013 | DOI: 10.1111/jnc.12029

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Spinosad is a macrocyclic lactone insecticide that acts on nicotinic acetylcholine receptors (nAChRs). We have cloned the nAChR α6 subunit from the western flower thrips Frankliniella occidentalis (Foα6) and have identified a single transmembrane point mutation that is associated with resistance to spinosad. Characterization of the mutation in recombinant nAChRs is consistent with spinosad having an allosteric mechanism of action.

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