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Yusuke Kondo, Masahiro To, Juri Saruta, Takashi Hayashi, Hiroki Sugiyama and Keiichi Tsukinoki Role of TrkB expression in rat adrenal gland during acute immobilization stress Journal of Neurochemistry 124

Version of Record online: 25 OCT 2012 | DOI: 10.1111/jnc.12030

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BDNF–TrkB interaction causes catecholamine release in adrenal medulla

Stress induces expression of tyrosine receptor kinase B (TrkB) in the adrenal medulla (Adm), but the role of TrkB expression is poorly understood. Here, we showed that activation of TrkB induces catecholamine release and expression of brain-derived neurotrophic factor (BDNF) in the Adm. During stress, BDNF–TrkB interaction may thus play a role in a positive feedback loop.

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