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Seok Soon Park, Hyun-Jung Jung, Yoon-Jeong Kim, Tae Kwan Park, Chaeyoung Kim, Heesun Choi, In Hee Mook-Jung, Edward H. Koo and Sun Ah Park Asp664 cleavage of amyloid precursor protein induces tau phosphorylation by decreasing protein phosphatase 2A activity Journal of Neurochemistry 123

Version of Record online: 25 OCT 2012 | DOI: 10.1111/jnc.12032

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Caspase activation is known to be important in mediating Alzheimer's pathology. Here, we found that C-terminal fragment of APP released by caspase cleavage directly interact with PP2A thereby increasing tau phosphorylation. This event intimately connected with Aβ which enhances caspase cleavage. Our results suggest that caspase cleavage of APP plays a role as a mediator of Aβ-induced tau pathology.

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