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Yoko Furukawa-Hibi, Jaesuk Yun, Taku Nagai and Kiyofumi Yamada Transcriptional suppression of the neuronal PAS domain 4 (Npas4) gene by stress via the binding of agonist-bound glucocorticoid receptor to its promoter Journal of Neurochemistry 123

Version of Record online: 25 OCT 2012 | DOI: 10.1111/jnc.12034

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Glucocorticoid reduced Npas4 promoter activity via the negative GRE, while restraint stress increased the binding of ligand-associated GR to Npas4 promoter in the hippocampus. Our findings suggest that transcription of Npas4 is down-regulated by stress via the binding of GR to its promoter.

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