Yun-Sik Choi, Kate Karelina, Diego Alzate-Correa, Kari R. Hoyt, Soren Impey, J. Simon Arthur and Karl Obrietan Mitogen- and stress-activated kinases regulate progenitor cell proliferation and neuron development in the adult dentate gyrus Journal of Neurochemistry 123
Throughout life, the subgranular zone (SGZ) neurogenic niche seeds the dentate gyrus with new neurons. In this study we examined the role of the ERK/MAPK effectors mitogen-stress activated kinases 1 and 2 (MSK1/2) in SGZ progenitor cell proliferation and neuron morphological maturation. The data presented here indicate that MSK1/2 play key roles in regulating basal and inducible SGZ progenitor proliferation as well as regulating the morphological maturation of adult-born neurons.
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