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Yun-Sik Choi, Kate Karelina, Diego Alzate-Correa, Kari R. Hoyt, Soren Impey, J. Simon Arthur and Karl Obrietan Mitogen- and stress-activated kinases regulate progenitor cell proliferation and neuron development in the adult dentate gyrus Journal of Neurochemistry 123

Version of Record online: 25 OCT 2012 | DOI: 10.1111/jnc.12035

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Throughout life, the subgranular zone (SGZ) neurogenic niche seeds the dentate gyrus with new neurons. In this study we examined the role of the ERK/MAPK effectors mitogen-stress activated kinases 1 and 2 (MSK1/2) in SGZ progenitor cell proliferation and neuron morphological maturation. The data presented here indicate that MSK1/2 play key roles in regulating basal and inducible SGZ progenitor proliferation as well as regulating the morphological maturation of adult-born neurons.

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