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Matthew R. Durk, Gary N.Y. Chan, Christopher R. Campos, John C. Peart, Edwin C. Y. Chow, Eason Lee, Ronald E. Cannon, Reina Bendayan, David S. Miller and K. Sandy Pang 1α,25-Dihydroxyvitamin D3-liganded vitamin D receptor increases expression and transport activity of P-glycoprotein in isolated rat brain capillaries and human and rat brain microvessel endothelial cells Journal of Neurochemistry 123

Version of Record online: 1 NOV 2012 | DOI: 10.1111/jnc.12041

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1α,25-Dihydroxyvitamin D3-Liganded Vitamin D Receptor Increases Expression and Transport Activity of P-Glycoprotein in Isolated Rat Brain Capillaries and Human and Rat Brain Microvessel Endothelial Cells

Exposure of rat (RBE4) and human (hCMEC/D3) brain microvessel endothelial cells to 1α,25-dihydroxyvitamin D3, the active ligand of the vitamin D receptor, resulted in upregualtion of the multidrug resistance protein 1 (MDR1) and its gene product, P-glycoprotein (P-gp) and reduced the cellular accumulation of rhodamine 6G (R6G) and human amyloid-beta 1-42 (hAβ42), a putative precursor of plaques in Alzheimer's disease. P-gp efflux function was susceptible to inhibition by PSC833.

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