Jonathon Hull, Maya El Hindy, Patrick G. Kehoe, Katy Chalmers, Seth Love and Myra E. Conway Distribution of the branched chain aminotransferase proteins in the human brain and their role in glutamate regulation Journal of Neurochemistry 123
Here, for the first time the branched chain aminotransferase proteins are mapped to the human brain. Consistent with rat models the cytosolic form is neuronal specific (a). However, unlike observed in rat, the mitochondrial form in humans is specifically distributed to endothelial cells of the vasculature (b) indicating an alternative mechanism of glutamate metabolism to that proposed in the rat astrocyte: neuronal shuttle.
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