Hongyu Li, Junbo Huang, Wanlu Du, Caixia Jia, Hailan Yao and Yizheng Wang TRPC6 inhibited NMDA receptor activities and protected neurons from ischemic excitotoxicity Journal of Neurochemistry 123
TRPC6 suppressed the [Ca2+]i elevation induced by NMDA and protected neurons from ischemic damage. The TRPC6 Tg mice had smaller infarct volume and better behavior performance than their WT littermates. Increase in TRPC6 activity could be a potential strategy for stroke prevention and therapy.
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