E-mail a Wiley Online Library Link

Da Shi, Su Xu, Jaylyn Waddell, Susanna Scafidi, Steven Roys, Rao P. Gullapalli and Mary C. McKenna Longitudinal in vivo developmental changes of metabolites in the hippocampus of Fmr1 knockout mice Journal of Neurochemistry 123

Version of Record online: 7 NOV 2012 | DOI: 10.1111/jnc.12048

Thumbnail image of graphical abstract

Fragile X syndrome is the most common inherited cause of mental retardation, often studied in Fmr1 knockout (KO) mice. Comparison of Fmr1 KO to wild type mice at postnatal days 18, 21, and 30 using in vivo MRI/MRS showed alterations of NAA, taurine and inositol in the developing hippocampus. These alterations could change osmoregulation, signal transduction and neuromodulation during synaptogenesis and early myelination which could contribute to the impaired CNS function in fragile X syndrome.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field