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Andrew J. Billnitzer, Irina Barskaya, Cailing Yin and Ruth G. Perez APP independent and dependent effects on neurite outgrowth are modulated by the receptor associated protein (RAP) Journal of Neurochemistry 124

Article first published online: 15 NOV 2012 | DOI: 10.1111/jnc.12051

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This study was performed to characterize the contributions of APP, sAPPα, LRP, and RAP on neurite outgrowth. Our data reveal that sAPPα alters neuronal morphology, and that ERK modulates RAP effects on neurite outgrowth, especially in the absence of APP. The results suggest that successful AD therapies should preserve protein interactions in order to sustain the synaptic connections underlying memory.

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