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Joana Gonçalves, Sofia Baptista, Mikkel V. Olesen, Carlos Fontes-Ribeiro, João O. Malva, David P. Woldbye and Ana P. Silva Methamphetamine-induced changes in the mice hippocampal neuropeptide Y system: implications for memory impairment Journal of Neurochemistry 123

Version of Record online: 1 NOV 2012 | DOI: 10.1111/jnc.12052

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Involvement of NPY Y2 receptors in METH-induced memory deficit

Our main goal was to evaluate the alterations of hippocampal neuropeptide Y (NPY) system induced by methamphetamine (METH) and the possible involvement of these changes in memory deficit induced by the drug. The present work highlights the importance of the hippocampal NPY system, and the functional relationship between Y2 receptors and AKT/mTOR pathway activation in memory impairment induced by METH. Thus, we may suggest that targeting this specific pathway or the modulation of Y2 receptor activity could provide interesting therapeutic approaches.

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