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Jia Zhang, Yan Fan, Ying Li, Hobart Zhu, Liang Wang and Meng-Yang Zhu Chronic social defeat up-regulates expression of the serotonin transporter in rat dorsal raphe nucleus and projection regions in a glucocorticoid-dependent manner Journal of Neurochemistry 123

Article first published online: 7 NOV 2012 | DOI: 10.1111/jnc.12055

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Chronic stress and dysfunction of the serotonergic system are etiologically related to depression. In an attempt to explore their interaction, we found that chronic social defeat upregulated expression of serotonin transporter in the DRN and the projection regions, which may induce an alteration of serotonin transformation in the brain. This interaction may account for the development of this disease.

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