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Sang-Ho Choi, Saba Aid, Luca Caracciolo, S. Sakura Minami, Takako Niikura, Yasuji Matsuoka, R. Scott Turner, Mark P. Mattson and Francesca Bosetti Cyclooxygenase-1 inhibition reduces amyloid pathology and improves memory deficits in a mouse model of Alzheimer's disease Journal of Neurochemistry 124

Article first published online: 21 NOV 2012 | DOI: 10.1111/jnc.12059

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The role of COX-1 in AD has not been considered carefully in part due to the presumed predominant role of COX-2 in neuroinflammation. Here we show that the COX-1 inhibitor SC-560 reduces amyloid deposits and improves memory deficits in 3 × Tg-AD mice. These results suggest that COX-1 should be further considered as a potential target for therapeutic intervention.

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