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Lucia Frau, Nicola Simola, Antonio Plumitallo and Micaela Morelli Microglial and astroglial activation by 3,4-methylenedioxymethamphetamine (MDMA) in mice depends on S(+) enantiomer and is associated with an increase in body temperature and motility Journal of Neurochemistry 124

Version of Record online: 15 NOV 2012 | DOI: 10.1111/jnc.12060

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MDMA is an amphetamine derivative with rewarding properties that can also induce neuroinflammation and neurodegeneration. Since two enantiomers of MDMA exist, it is fundamental to know the relative efficacy of each of them. This study demonstrates that S(+)-MDMA is the main responsible of the neuroinflammatory effects of racemic MDMA. The results underline the importance of studying chirality in MDMA-induced neurotoxicity and neuroinflammation.

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