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Sanne S. Kaalund, Jesper Riise, Brian V. Broberg, Katrine Fabricius, Anna S. Karlsen, Thomas Secher, Niels Plath and Bente Pakkenberg Differential expression of parvalbumin in neonatal phencyclidine-treated rats and socially isolated rats Journal of Neurochemistry 124

Article first published online: 25 DEC 2012 | DOI: 10.1111/jnc.12061

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Decreased parvalbumin (PV) expression is a pathophysiological hallmark of schizophrenia associated with cognitive deficits. Using a stereological approach we report a loss of parvalbumine-positive interneurons in the prefrontal cortex of the neonatal PCP rat model. The translational aspect favours the use of the model in future studies aiming at unravelling the role of parvalbumin-positive interneurons in cortical dysfunction.

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