Mireia Herrando-Grabulosa, Caty Casas and José Aguilera The C-terminal domain of tetanus toxin protects motoneurons against acute excitotoxic damage on spinal cord organotypic cultures Journal of Neurochemistry 124
One of the main processes that induces motoneuron (MN) cell death is the excitotocity triggered after Spinal Cord Injury (SCI). C-terminal domain of tetanus toxin (Hc-TeTx domain) protects motoneurons against this damage by activating several pro-survival signalling pathways, such as autophagy. Hc-TeTx could be useful as a neuroprotector agent to promotes MN survival.
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