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Koro Gotoh, Takayuki Masaki, Seiichi Chiba, Hisae Ando, Takanobu Shimasaki, Kimihiko Mitsutomi, Kansuke Fujiwara, Isao Katsuragi, Tetsuya Kakuma, Toshiie Sakata and Hironobu Yoshimatsu Nesfatin-1, corticotropin-releasing hormone, thyrotropin-releasing hormone, and neuronal histamine interact in the hypothalamus to regulate feeding behavior Journal of Neurochemistry 124

Article first published online: 15 NOV 2012 | DOI: 10.1111/jnc.12066

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Nesfatin-1, corticotropin-releasing hormone (CRH), thyrotropin-releasing hormone (TRH) and hypothalamic neuronal histamine act as anorexigenics in the hypothalamus. Nesfatin-1 increased CRH and TRH levels and histamine turnover, whereas histamine also increased nesfatin-1 level in the hypothalamus. These results indicate that CRH, TRH and hypothalamic neuronal histamine mediate the suppressive effects of nesfatin-1 on feeding behavior.

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