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Dirk W. Luchtman, Qingjia Meng, Xiaofeng Wang, Di Shao and Cai Song Omega-3 fatty acid eicospentaenoic acid attenuates MPP+-induced neurodegeneration in fully differentiated human SH-SY5Y and primary mesencephalic cells Journal of Neurochemistry 124

Article first published online: 13 JAN 2013 | DOI: 10.1111/jnc.12068

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Omega-3 fatty acids may be effective as a potential therapeutic compound against Parkinson's disease (PD), but research is still in its infancy. Herein, we show that omega-3 fatty acid eicosapentaenoic acid (EPA) prevents neurodegeneration induced by Parkinsonian toxin MPP+ in SH-SY5Y cells and primary mesencephalic neurons. Several experiments show that mechanisms of protection are antioxidant, anti-inflammatory, neurotrophic, and antiapoptotic action.

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