Weina Ju, Qi Li, Yohance M. Allette, Matthew S. Ripsch, Fletcher A. White and Rajesh Khanna Suppression of pain-related behavior in two distinct rodent models of peripheral neuropathy by a homopolyarginine-conjugated CRMP2 peptide Journal of Neurochemistry 124
Chronic neuropathic pain remains a worldwide medical problem with few effective therapies. Drugs targeting calcium channels are in clinical use as first-line treatments for alleviation of neuropathic pain. However, targeting these channels can lead to serious complications. Here, we report that a peptide derived from CRMP2 – a modulator of calcium channels, offers problem-free pain relief in rodent models of neuropathic pain.
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