Ying-Ju Chen, Sue Oldfield, Adrian J. Butcher, Andrew B. Tobin, Kunal Saxena, Vsevolod V. Gurevich, Jeffrey L. Benovic, Graeme Henderson and Eamonn Kelly Identification of phosphorylation sites in the COOH-terminal tail of the μ-opioid receptor Journal of Neurochemistry 124
This study was performed to identify sites in the C-terminal tail of the μ-opioid receptor (MOPr) that are phosphorylated. We found that the C-terminal tail of the receptor is phosphorylated at multiple sites, and that different kinases are likely to mediate these phosphorylation events. This is important because it suggests that multiple kinases regulate the signaling, desensitization and trafficking of MOPr.
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