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Natalia VanDuyn, Raja Settivari, Jennifer LeVora, Shaoyu Zhou, Jason Unrine and Richard Nass The metal transporter SMF-3/DMT-1 mediates aluminum-induced dopamine neuron degeneration Journal of Neurochemistry 124

Article first published online: 21 NOV 2012 | DOI: 10.1111/jnc.12072

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Aluminum exposure is a risk factor for Parkinson's disease and Alzheimer's disease, yet the molecular basis for intracellular Al transport and neurotoxicity is poorly defined. We developed a novel model for aluminum-induced dopamine neuron degeneration and provide the first molecular evidence of an animal aluminum transporter. This novel genetic model should facilitate the identification of molecular pathways and potential therapeutic targets involved in Al-associated DA neuron degeneration. Graphical abstract designed by Richard Nass and Albert William.

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