Tanja Dučić, Elisabeth Barski, Murielle Salome, Jan C. Koch, Mathias Bähr and Paul Lingor X-ray fluorescence analysis of iron and manganese distribution in primary dopaminergic neurons Journal of Neurochemistry 124
Synchrotron X-ray fluorescence microscopy was performed to reveal the distribution of iron and manganese in primary midbrain neuron cultures. Mn2+ was preferably accumulated in dopaminergic neurons correlating with an increased expression of voltage-gated calcium channels. Stronger Mn uptake may thus result in increased oxidative stress and contribute to the vulnerability of dopaminergic nigrostriatal projections in the pathogenesis of Parkinson's disease.
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