Antoine G. Almonte, Laura H. Qadri, Faraz A. Sultan, Jennifer A. Watson, Daniel J. Mount, Gavin Rumbaugh and J. David Sweatt Protease-activated receptor-1 modulates hippocampal memory formation and synaptic plasticity Journal of Neurochemistry 124
PAR1 is an intriguing GPCR that is activated by proteolytic cleavage of its amino terminus by serine proteases; very little is known, however, about PAR1 in normal brain function. We show that PAR1 knockout mice have deficits in a hippocampus-dependent learning and memory behavioral test, and have severe deficits in NMDAR-dependent LTP. Our results suggest an important role for PAR1 function in NMDAR-dependent processes subserving memory formation and synaptic plasticity.
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