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Dimitrios E. Kouzoukas, Guiying Li, Maysaam Takapoo, Thomas Moninger, Ramesh C. Bhalla and Nicholas J. Pantazis Intracellular calcium plays a critical role in the alcohol-mediated death of cerebellar granule neurons Journal of Neurochemistry 124

Version of Record online: 6 DEC 2012 | DOI: 10.1111/jnc.12076

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Intracellular calcium plays a critical role in the alcohol-mediated death of cerebellar granule neurons Alcohol triggers neuronal death in the developing brain by an unknown mechanism. Since disruption of intracellular calcium [Ca2+]i is linked to cell death, we investigated the role of [Ca2+]i in alcohol-induced cell death. Experiments with neuronal cultures demonstrated that alcohol releases calcium from intracellular stores, producing a sustained [Ca2+]i increase and neuronal death. Preventing this rise in [Ca2+]i ameliorated cell death, suggesting a key role for [Ca2+]i in alcohol neurotoxicity.

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