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Hiren R. Modi, Ameer Y. Taha, Hyung-Wook Kim, Lisa Chang, Stanley I. Rapoport and Yewon Cheon Chronic clozapine reduces rat brain arachidonic acid metabolism by reducing plasma arachidonic acid availability Journal of Neurochemistry 124

Version of Record online: 6 DEC 2012 | DOI: 10.1111/jnc.12078

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The atypical antipsychotic clozapine, like olanzapine, downregulates rat brain arachidonic acid (AA) metabolism (cyclooxygenase activity and PGE2 concentration) by reducing plasma unesterified AA concentration and AA incorporation rate Jin into brain phospholipids. Brain AA incorporation coefficient k* (uptake affinity) is increased. Thus two atypical antipsychotics, like mood stabilizers, may act in bipolar disorder by dampening its upregulated brain AA metabolism.

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