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Ebba Gregorsson Lundius, Nikolas Stroth, Vladana Vukojević, Lars Terenius and Per Svenningsson Functional GPR37 trafficking protects against toxicity induced by 6-OHDA, MPP+ or rotenone in a catecholaminergic cell line Journal of Neurochemistry 124

Article first published online: 6 DEC 2012 | DOI: 10.1111/jnc.12081

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Functional GPR37 trafficking protects against toxicity induced by 6-OHDA, MPP+ or rotenone in a catecholaminergic cell line: GPR37 is an orphan receptor implicated in Parkinson's disease. Previous work has shown that aggregated GPR37 is accumulated in Lewy bodies and promotes cell death. In contrast, this study shows that functionally trafficked GPR37 counteracts cell death induced by three different dopaminergic toxins. Moreover, catecholaminergic neuronal differentiation leads to increased receptor levels at the plasma membrane and enhanced receptor-mediated protection.

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