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Nieves Herrera-Mundo and María Sitges Vinpocetine and α-tocopherol prevent the increase in DA and oxidative stress induced by 3-NPA in striatum isolated nerve endings Journal of Neurochemistry 124

Version of Record online: 5 DEC 2012 | DOI: 10.1111/jnc.12082

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This study investigates the potential capacity of vinpocetine to overcome damage exerted by 3-NPA on brain dopamine (DA)-rich structures. 3-NPA inhibits MAO activity, increases production of reactive oxygen species (ROS) and harmful DA-quinone products. Vinpocetine decreases DA uptake into synaptic vesicles, increases DA metabolism to DOPAC, and by this means prevents the particular damage exerted by 3-NPA in brain DA-rich structures. Drugs that increase DA and free radicals simultaneously, like 3-NPA, exacerbate the oxidative damage by harmful DA–quinone products. On the other hand, drugs that decrease DA and simultaneously act as antioxidants, like vinpocetine and α-tocopherol, are effective neuroprotective agents.

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