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Kurt T. Laha and Phu N. Tran Multiple tyrosine residues at the GABA binding pocket influence surface expression and mediate kinetics of the GABAA receptor Journal of Neurochemistry 124

Version of Record online: 30 NOV 2012 | DOI: 10.1111/jnc.12083

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Multiple tyrosine residues at the GABA binding pocket influence surface expression and mediate kinetics of the GABA(A) receptorSeveral tyrosine residues are located in the GABA binding pocket of the GABA(A) receptor, but specific contributions of each residue to receptor function are not fully understood. We found that mutating each tyrosine specifically slowed the GABA binding rate. This detailed kinetic characterization of binding pocket mutations will aid the description of how neurotransmitter binding leads to receptor activation.

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