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Mitsunari Nakajima, Hisamichi Mori, Chisa Nishikawa, Momoko Tsuruta, Satoshi Okuyama and Yoshiko Furukawa Psychiatric disorder-related abnormal behavior and habenulointerpeduncular pathway defects in Wnt1-cre and Wnt1-GAL4 double transgenic mice Journal of Neurochemistry 124

Version of Record online: 5 DEC 2012 | DOI: 10.1111/jnc.12085

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We found that a Wnt1-cre deleter mouse line for Cre/LoxP system exhibits psychiatric disorder-related behavioral abnormalities and abnormal cholinergic and glutamatergic fiber tracts in the interpeduncular nucleus derived from the neural crest. We propose that irregular development of the neural crest-derived cells might be involved in the pathogenesis of psychiatric disorders.

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