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Tiago G. Santos, Flavio H. Beraldo, Glaucia N. M. Hajj, Marilene H. Lopes, Martin Roffe, Fernanda C. S. Lupinacci, Valeriy G. Ostapchenko, Vania F. Prado, Marco A. M. Prado and Vilma R. Martins Laminin-γ1 chain and stress inducible protein 1 synergistically mediate PrPC-dependent axonal growth via Ca2+ mobilization in dorsal root ganglia neurons Journal of Neurochemistry 124

Article first published online: 4 DEC 2012 | DOI: 10.1111/jnc.12091

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The role of PrPCmultiprotein complexes in sensory neurons was explored using several combinations of two of its ligands, the extracellular matrix protein laminin (or a peptide fromlamininγ1 chain comprising PrPC binding site) and the secreted co-chaperone STI1. We found a synergistic effect of these two ligands upon axonogenesis that depends on the presence of PrPC. Furthermore, these effects occur through intracellular calcium mobilization mechanisms and require TRPC channel activation, rather than mGluR1, which is involved only in laminin-γ1 pathways.

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