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Nicola J. Robertson, Takenori Kato, Alan Bainbridge, Manigandan Chandrasekaran, Osuke Iwata, Andrew Kapetanakis, Stuart Faulkner, Jeanie Cheong, Sachiko Iwata, Mariya Hristova, Ernest Cady and Gennadij Raivich Methyl-isobutyl amiloride reduces brain Lac/NAA, cell death and microglial activation in a perinatal asphyxia model Journal of Neurochemistry 124

Version of Record online: 26 DEC 2012 | DOI: 10.1111/jnc.12097

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Methyl-isobutyl amiloride is neuroprotective in a perinatal asphyxia modelIn a translational piglet hypoxia-ischemia model with real time monitoring and intensive care support on par with the clinic, we demonstrate neuroprotection with methyl isobutyl amiloride (MIA), a N+/H+ exchanger (NHE) inhibitor, administered 10 mins after global cerebral hypoxia-ischemia. Correlating with improved cerebral energy metabolism on the proton magnetic resonance spectroscopy biomarker (eg. N acetyl aspartate (NAA)/Creatine), we saw a reduction in histological parameters of brain damage.

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