Nicola J. Robertson, Takenori Kato, Alan Bainbridge, Manigandan Chandrasekaran, Osuke Iwata, Andrew Kapetanakis, Stuart Faulkner, Jeanie Cheong, Sachiko Iwata, Mariya Hristova, Ernest Cady and Gennadij Raivich Methyl-isobutyl amiloride reduces brain Lac/NAA, cell death and microglial activation in a perinatal asphyxia model Journal of Neurochemistry 124
Methyl-isobutyl amiloride is neuroprotective in a perinatal asphyxia modelIn a translational piglet hypoxia-ischemia model with real time monitoring and intensive care support on par with the clinic, we demonstrate neuroprotection with methyl isobutyl amiloride (MIA), a N+/H+ exchanger (NHE) inhibitor, administered 10 mins after global cerebral hypoxia-ischemia. Correlating with improved cerebral energy metabolism on the proton magnetic resonance spectroscopy biomarker (eg. N acetyl aspartate (NAA)/Creatine), we saw a reduction in histological parameters of brain damage.
Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf