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Shunhui Wei, Stephanie Li-Ying Soh, Wenjie Qiu, Wulin Yang, Cheyenne Jia-Yan Seah, Jing Guo, Wei-Yi Ong, Zhiping P. Pang and Weiping Han Seipin regulates excitatory synaptic transmission in cortical neurons Journal of Neurochemistry 124

Version of Record online: 27 DEC 2012 | DOI: 10.1111/jnc.12099

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Seipin, an ER protein with high-level expression in brain, is implicated in a broad spectrum of motoneuron diseases. Seipin specifically regulates excitatory postsynaptic currents (EPSCs) as knockdown (KD) of Seipin results in significantly reduced AMPA receptor (AMPA-R)-mediated currents. Moreover, Seipin KD causes decreased total and surface AMPA-R levels. We conclude that Seipin regulates synaptic transmission through a postsynaptic mechanism.

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