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Pranjal Nahar-Gohad, Hamidah Sultan, Ysabella Esteban, Alyda Stabile and Jane L. Ko RACK1 identified as the PCBP1-interacting protein with a novel functional role on the regulation of human MOR gene expression Journal of Neurochemistry 124

Article first published online: 26 DEC 2012 | DOI: 10.1111/jnc.12100

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RACKing up a New Regulatory Role: The human MOR gene is regulated by many factors, including PCBP1. Using the two-hybrid screening study with a human brain cDNA library, the authors identified RACK1 and showed that it physically interacts with PCBP1 mainly via WD7 domain and regulates MOR expression. This report adds to the variety of RACK1 interactions and provides further information how cells regulate MOR expression.

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