Anthony J. Baucum II, Abigail M. Brown and Roger J. Colbran Differential association of postsynaptic signaling protein complexes in striatum and hippocampus Journal of Neurochemistry 124
The organization of postsynaptic signaling proteins in different brain regions is poorly understood. We found that the protein phosphatase 1 binding protein, spinophilin, and CaMKII associated more robustly with each other and with the GluN2B NMDAR subunit in a striatal extrasynaptic fraction compared to the hippocampus. These data demonstrate brain region- and subcellular fraction-specific differences in synaptic protein organization.
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