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Anthony J. Baucum II, Abigail M. Brown and Roger J. Colbran Differential association of postsynaptic signaling protein complexes in striatum and hippocampus Journal of Neurochemistry 124

Version of Record online: 26 DEC 2012 | DOI: 10.1111/jnc.12101

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The organization of postsynaptic signaling proteins in different brain regions is poorly understood. We found that the protein phosphatase 1 binding protein, spinophilin, and CaMKII associated more robustly with each other and with the GluN2B NMDAR subunit in a striatal extrasynaptic fraction compared to the hippocampus. These data demonstrate brain region- and subcellular fraction-specific differences in synaptic protein organization.

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